2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138024
    Tacapenem
    Tacapenem (R-95867), the active metabolite of CS-834, is an antibacterial agent. Tacapenem exhibits a broad antibacterial spectrum, with activity against gram-positive and -negative aerobes and anaerobes. Tacapenem shows potent bactericidal activity against S. aureus and Escherichia coli.
    Tacapenem
  • HY-170697
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide
  • HY-W705371
    α-Hydroxy etizolam
    α-Hydroxy etizolam is the primary metabolite of Etizolam, possessing nearly identical pharmacological potency and high affinity for benzodiazepine receptors as Etizolam.
    α-Hydroxy etizolam
  • HY-172233
    INCB-056868
    INCB-056868 is the metabolite M11 of Epacadostat (HY-15689). INCB-056868 can also serve as a substrate for BCRP. INCB-056868 is promising for research of metabolic diseases.
    INCB-056868
  • HY-165546
    AGI-16903
    AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC50 values of 100 nM and 400 nM against IDH2R140Q and IDH2R172K, respectively.
    AGI-16903
  • HY-10873S1
    N-Desethyl Sunitinib-d4 TFA
    N-Desethyl Sunitinib-d4 (SU-12662-d4) TFA is deuterium-labeled N-Desethyl Sunitinib (HY-10873).
    N-Desethyl Sunitinib-d<sub>4</sub> TFA
  • HY-W099987
    4-tert-Amylphenol
    4-tert-Amylphenol is the hydrolysis product of the mixture of phosphorous acid 2,4-bis (1,1-dimethylpropyl) phenyl ester and phosphorous acid 4-(1,1-dimethylpropyl) phenyl triester.
    4-tert-Amylphenol
  • HY-Z7659
    Lansoprazole sulfone N-Oxide
    Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
    Lansoprazole sulfone N-Oxide
  • HY-108226
    Regorafenib N-oxide and N-desmethyl (M5)
    Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4.
    Regorafenib N-oxide and N-desmethyl (M5)
  • HY-B0300R
    Penicillamine (Standard)
    Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
    Penicillamine (Standard)
  • HY-136456R
    2-NP-AMOZ (Standard)
    2-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
    2-NP-AMOZ (Standard)
  • HY-W615141
    Desmethyltrimipramine
    		98.03%
    Desmethyltrimipramine (DTRI) is a metabolite of Trimipramine (HY-B1213A) (a 5-HT receptor antagonist and antidepressant).
    Desmethyltrimipramine
  • HY-114750R
    Mebendazole-amine (Standard)
    Mebendazole-amine (Standard) is the analytical standard of Mebendazole-amine. This product is intended for research and analytical applications. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine (Standard)
  • HY-A0154R
    Deslanoside (Standard)
    Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
    Deslanoside (Standard)
  • HY-177966
    ETM-305
    ETM-305 is a degradation product of the anticancer agent ET-743 (HY-50936). ET-743 (Ecteinascidin 743; Trabectedin) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks the transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cell apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin is used in the research of soft tissue sarcoma and ovarian cancer.
    ETM-305
  • HY-171043
    3-Hydroxy desalkylgidazepam
    3-Hydroxy desalkylgidazepam (compound 2) is the active metabolite of Gidazepam (HY-U00315) and Desalkylgidazepam (HY-W634748).
    3-Hydroxy desalkylgidazepam
  • HY-W587516
    Bisphenol A bissulfate disodium
    Bisphenol A bissulfate disodium is a metabolite of Bisphenol A (HY-18260). Bisphenol A bissulfate disodium (compound 7) show complement-inhibiting activity with an IC50 of 247 μM.
    Bisphenol A bissulfate disodium
  • HY-W335576
    3-(Methylphosphinico)propionic acid
    3-(Methylphosphinico)propionic acid serves as a metabolite of the pesticide glufosinate ammonium.
    3-(Methylphosphinico)propionic acid
  • HY-101433R
    N-Acetylprocainamide hydrochloride (Standard)
    N-Acetylprocainamide (Acecainide) hydrochloride (Standard) is the analytical standard of N-Acetylprocainamide hydrochloride (HY-101433). This product is intended for research and analytical applications. N-Acetylprocainamide hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.
    N-Acetylprocainamide hydrochloride (Standard)
  • HY-128406
    Morinidazole metabolite-1
    Morinidazole metabolite-1 (Compound M4-1) is a metabolite of Morinidazole (HY-15781).
    Morinidazole metabolite-1
Cat. No. Product Name / Synonyms Application Reactivity